Journal of Pharmaceutical Sciences and Research

Many brands of paracetamol tablets are available as over the counter product (OTC ) in India which are widely used for analgesic and antipyretic effect. This study was conducted to compare and evaluate the different brands of paracetamol tablets available in the drug stores. Five different brands of paracetamol tablets were collected from various pharmacy shops and tested as per selected pharmacopeial and non-pharmacopoeial quality control tests. The parameters assessed includes the weight variation, friability, hardness, identification and disintegration time, The evaluation results indicate that all brands met the acceptable limits except for two brands that marginally failed the friability test. However, since friability is not considered as a Critical Quality Attribute in final product specifications, these tablets cannot be claimed as “failure to meet Quality Standards”. Hence all brands ensure the safety and efficacy for consumer use at preliminary stage of evaluation. Further assessment, including critical quality control test should be conducted as part of the continuous assessment of the quality of marketed products.