Journal of Pharmaceutical Sciences and Research

ODTs are gaining significant importance in the pharmaceutical industry due to their ability to improve patient compliance, enhance drug bioavailability, and provide accurate dosing compared to conventional formulations. They disintegrate rapidly in the oral cavity, typically within less than one minute, resulting in easy-to-swallow residue that benefits pediatric and geriatric patients. Advanced methods like freeze-drying, spray-drying, effervescent techniques, and patented technologies like microencapsulation and nanocrystals have been employed to mask the bitter taste of drugs, ensuring better patient acceptance. Challenges such as reducing manufacturing costs, improving packaging, enhancing mechanical strength, and effective taste masking are being addressed through ongoing research.