Abstract
Background: Diabetes management remains a significant challenge, with traditional insulin therapies often requiring frequent injections and dose adjustments. Intelligent insulin, a novel class of glucose-responsive insulin formulations, has emerged as a promising solution.
Objective: To conduct a systematic review of intelligent insulin formulations, evaluating their efficacy, safety, and clinical potential.
Methods: A comprehensive literature search was conducted across multiple databases, including PubMed, Scopus, and Web of Science. Studies evaluating intelligent insulin formulations in vitro, in vivo, or in clinical trials were eligible for inclusion.
Results: A total of 25 studies met the inclusion criteria, demonstrating improved glucose control, reduced hypoglycemia risk, and enhanced patient convenience with intelligent insulin formulations.
Conclusion: Intelligent insulin formulations show promising potential for improving diabetes management. Further research is necessary to fully evaluate their safety and efficacy, and to establish their role in clinical practice.
Keywords: intelligent insulin, glucose-responsive insulin, diabetes management, systematic review
